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Sponge Enzymes and Cells for Innovative AppLications

Reference no: FP7-KBBE-2010-4
Acronym: SPECIAL
Period: December 2010 till November 2013
Status: Completed

Institutes (9)  Top 
  • University of Minho (UMINHO), more, co-ordinator
  • Tel-Aviv University, more, partner
  • Porifarma, more, partner
  • Studio Associato Gaia, more, partner
  • University of Genova, more, partner
  • Chinese Academy of Sciences; National Research Center for Geoanalysis, more, partner
  • Karolinska Institute, more, partner
  • Atrahasis srl, more, partner
  • NanotecMARIN GmbH, more, partner

The SPECIAL project aims at delivering breakthrough technologies for the biotechnological productions of cellular metabolites and extracellular biomaterials from marine sponges.
These include a platform technology to produce secondary metabolites from a wide range of sponge species, a novel in vitro method for the production of biosilica and recombinant technology for the production of marine collagen. Research on cellular metabolites will be based upon our recent finding that non-growing sponges continuously release large amounts of cellular material.
Production of biosilica will be realized through biosintering, a novel enzymatic process that was recently
discovered in siliceous sponges. Research on sponge collagen will focus on finding the optimal conditions for expression of the related genes. Alongside this research, the project will identify and develop new products from sponges, thus fully realizing the promises of marine biotechnology. Specifically, the project will focus on potential anticancer drugs and novel biomedical/industrial applications of biosilica and collagen, hereby taking advantage of the unique physico-chemical properties of these extracellular sponge products.
The consortium unites seven world-class research institutions covering a wide range of marine biotechnology-related disciplines and four knowledge-intensive SMEs that are active in the field of sponge culture, drug development and nanobiotechnology.
The project is clearly reflecting the strategic objectives outlined in the position paper European Marine Strategy (2008); it will enhance marine biotechnology at a multi-disciplinary, European level and provide new opportunities for the European industry to exploit natural marine resources in a sustainable way. In particular the biotechnological potential of marine sponges, which has for a long time been considered as an eternal promise, will be realized through the SPECIAL project.

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